2-(4-(chloromethyl)-4-hydroxy-2-thiazolin-2-yl)guanidine hydrochloride
CAS: 95907-33-8
Category: Pharmaceutical Intermediates
| Purity | ≥98.0% (HPLC), ≥99.0% (HPLC) |
| Molecular Formula | C5H10Cl2N4OS |
| Molecular Weight | 245.13 |
| Appearance | White to off-white crystalline powder |
| Packaging | 1 g, 5 g, 25 g, 100 g, 500 g, 1 kg, or 5 kg HDPE bottle or aluminum foil bag with double polyethylene inner liner |
| Testing Indicators | Appearance — Visual inspection; Identification — HPLC retention time, FTIR, LC-MS, 1H NMR and 13C NMR; Assay/Purity — HPLC (UV); Related substances — HPLC; Water content — Karl Fischer titration (USP <921>); Residual solvents — GC (USP <467>); Chloride content — Argentometric titration or ion chromatography; Heavy metals — ICP-MS or ICP-OES; Residue on ignition — USP <281>; Particle size — Laser diffraction (when specified). |
| Storage Notes | Store in a tightly closed container in a cool, dry, well-ventilated place at 2–8°C. Protect from moisture, direct sunlight, and excessive heat. For extended storage, maintain under an inert atmosphere. Avoid contact with strong oxidizing agents, strong bases, and excessive humidity. |
| Lead Time | 10 days |
An important pharmaceutical intermediate used in the synthesis of famotidine and related histamine H2 receptor antagonists. It is employed in medicinal chemistry, process development, and commercial API manufacturing involving thiazole-containing pharmaceutical compounds.