3,5-Dichloro-2,6-difluoro-4-pyridinol
CAS: 2693-61-0
Category: Pharmaceutical Intermediates
| Purity | Research Grade ≥95%, High-Purity Grade ≥98%, Pharmaceutical Intermediate Grade ≥99%, Analytical Refe |
| Molecular Formula | C₅HCl₂F₂NO |
| Molecular Weight | 199.97 |
| Appearance | White to off-white to light beige crystalline powder |
| Packaging | 1g/5g/10g/25g/100g/500g/plastic bottle or aluminum foil bag; 1kg/5kg/25kg/fiber drum or plastic drum; custom packaging for bulk orders |
| Testing Indicators | Appearance — Visual inspection; Identification — NMR (¹H, ¹³C, ¹⁹F), FTIR, or LC-MS; Purity — HPLC (C18 column, UV detection at 220–280 nm); Melting point — Capillary method; Water content — Karl Fischer titration or loss on drying; Residual solvents — GC; Heavy metals — ICP-MS; Related impurities (isomers, dehalogenated byproducts) — HPLC; Halogen content (total Cl + F) — Elemental analysis or ion chromatography after combustion; Assay — Titration (non-aqueous acid-base) or HPLC. |
| Storage Notes | Stored in a tightly sealed container in a cool, dry, well-ventilated area, protected from light and moisture; away from strong oxidizers, strong bases, strong acids, and heat sources; stable at room temperature; keep container closed when not in use. |
| Lead Time | days |
Used as a pharmaceutical intermediate and agrochemical intermediate; as a building block for the synthesis of antibacterial agents, antifungal compounds, and herbicides; the hydroxyl group at the 4-position allows for further functionalization (esterification, etherification, alkylation); the halogen substituents (Cl, F) provide sites for cross-coupling reactions (e.g., Suzuki-Miyaura, Buchwald-Hartwig) and influence lipophilicity and metabolic stability; used in medicinal chemistry for structure-activity relationship (SAR) studies of pyridine-based bioactive molecules.