Methyl (E)-4-(2,4,5-trifluorophenyl)but-2-enoate
CAS: 1260029-44-4
Category: Organic Pharmaceutical Intermediates
| Purity | Research Grade ≥95%; High Purity Grade ≥98%; Pharmaceutical Intermediate Grade ≥99% |
| Molecular Formula | C11H9F3O2 |
| Molecular Weight | 230.18 |
| Appearance | Colorless to pale yellow transparent liquid or crystalline solid with slight organic odor |
| Packaging | 100 g, 500 g, 1 kg aluminum foil bag; 5 kg, 25 kg fiber drum or HDPE container with inner liner |
| Testing Indicators | Appearance — Visual inspection; Purity — HPLC or GC analysis; Identification — 1H NMR, 13C NMR and 19F NMR spectroscopy; Molecular structure confirmation — LC-MS or HRMS; Residual solvents — GC analysis according to ICH Q3C guidelines; Water content — Karl Fischer titration; Related substances — HPLC impurity profile; Melting point — Capillary method (for solid samples). |
| Storage Notes | Store in a cool, dry, well-ventilated warehouse away from direct sunlight and heat sources. Keep container tightly sealed and protected from moisture. Avoid contact with strong acids, strong bases, oxidizing agents, and reducing agents. Store under inert atmosphere when long-term storage is required. |
| Lead Time | 10 days |
Used as a pharmaceutical intermediate, particularly as a key building block in the synthesis of fluorinated active pharmaceutical ingredients. The compound contains a trifluorophenyl group and an α,β-unsaturated ester structure, making it suitable for further chemical transformations such as hydrogenation, substitution, and coupling reactions in medicinal chemistry research.