4-Biphenylcarbonyl chloride
CAS: 14002-51-8
Category: Organic Intermediates
| Purity | Technical Grade ≥90%, Reagent Grade ≥95%, High-Purity Grade ≥97%, Research Grade ≥98%, Pharmaceutica |
| Molecular Formula | C₁₃H₉ClO |
| Molecular Weight | 216.66 |
| Appearance | White to off-white to pale yellow crystalline solid (may be light-sensitive and discolor upon storage) |
| Packaging | 5g/10g/25g/50g/100g/250g/500g/glass bottle or PTFE-lined glass bottle; 1kg/5kg/25kg/plastic drum or fiber drum with PTFE liner; packaged under inert atmosphere (nitrogen or argon) with moisture-proof seals |
| Testing Indicators | Appearance — Visual inspection (white to off-white crystals; yellowing indicates degradation); Identification — NMR (¹H, ¹³C), FTIR (characteristic acyl chloride C=O stretch ~1750–1800 cm⁻¹, often split or broadened), or GC-MS; Purity — GC-FID or HPLC (C18 column, UV detection at 254 nm); Melting point — Capillary method (reported range: 89–92°C, varies with purity); Assay — Titration (silver nitrate for chloride after hydrolysis) or HPLC; Water content — Karl Fischer titration (critical parameter); Free carboxylic acid content (biphenyl-4-carboxylic acid impurity) — HPLC or acid-base titration; Residual solvents — GC; Heavy metals — ICP-MS. |
| Storage Notes | Stored in a tightly sealed, moisture-proof container (glass or PTFE-lined) under inert atmosphere (nitrogen or argon) in a cool, dry, well-ventilated area; protected from light and moisture; away from strong bases, strong oxidizers, alcohols, amines, water, and heat sources; store at 2–8°C (refrigerated) for long-term stability; handle with strict moisture control (reacts with water). |
| Lead Time | days |
Used as a synthetic intermediate in organic chemistry and pharmaceutical research; for the introduction of the biphenyl-4-carbonyl (4-phenylbenzoyl) group via acylation reactions (Schotten-Baumann conditions); in the synthesis of biphenyl-containing amides, esters, ketones, and heterocyclic compounds; as a building block for liquid crystals, pharmaceuticals (e.g., angiotensin II receptor antagonists, anti-inflammatory agents), agrochemicals, and organic electronic materials; in the preparation of polymer precursors, photoinitiators, and fluorescent probes.