Sermorelin
CAS: 86168-78-7
Category: Peptides
| Purity | Pharmaceutical Grade (GMP-compliant, sterile, ≥98% by HPLC), Research Grade ≥97%, Analytical Referen |
| Molecular Formula | C149H246N44O42S |
| Molecular Weight | 3357.9 |
| Appearance | White to off-white lyophilized powder |
| Packaging | 0.5mg/1mg/2mg/5mg/vial (lyophilized for injection); 10mg/20mg/vial (for research); multi-dose vials with bacteriostatic water kit; bulk packaging for pharmaceutical manufacturing |
| Testing Indicators | Appearance — Visual inspection; Identification — HPLC-MS or MALDI-TOF; Purity — HPLC (C18 column, UV detection at 214–220 nm); Peptide content — Amino acid analysis or UV spectrophotometry (A280); Acetate content (counterion) — Ion chromatography; Water content — Karl Fischer titration; Residual solvents — GC; Bacterial endotoxins — LAL test; Sterility — Membrane filtration or direct inoculation (for pharmaceutical grade); Mass verification — Mass spectrometry (ESI or MALDI); Sequence verification — Edman degradation or MS/MS; Bioactivity — GH release assay (pituitary cell culture or in vivo); Related substances (deamidated, oxidized, truncated forms) — HPLC-MS. |
| Storage Notes | Stored as lyophilized powder at 2–8°C (refrigerated) for short-term or -20°C for long-term; reconstituted solutions should be stored at 2–8°C and used within 14–28 days (depending on preservative, e.g., bacteriostatic water with benzyl alcohol); protected from light; avoid repeated freeze-thaw cycles; away from heat, moisture, and proteases. |
| Lead Time | days |
Used as a diagnostic agent for assessment of growth hormone (GH) reserve (to evaluate pituitary function); used therapeutically for the treatment of growth hormone deficiency (GHD) in children and adults; acts as a synthetic analog of the endogenous 44-amino acid GHRH (contains the first 29 amino acids, which constitute the biologically active region); stimulates the pituitary gland to secrete endogenous growth hormone (GH); also studied for anti-aging applications, improvement of sleep quality, and enhancement of immune function (off-label/experimental).