Tesamorelin
CAS: 218949-48-5
Category: Peptides
| Purity | Pharmaceutical/GMP Grade (≥99% by HPLC, low endotoxin); Acetate salt form (most common for injectabl |
| Molecular Formula | C₂₂₁H₃₆₆N₇₂O₆₈S |
| Molecular Weight | Approximately 5135.9 g/mol (free base) or ~5.2 kDa |
| Appearance | White to off-white lyophilized powder |
| Packaging | 1 mg/vial, 2 mg/vial, 5 mg/vial (for research or clinical reconstitution); 1g/5g/10g per aluminum foil bag or glass vial (for bulk API); larger custom packaging for pharmaceutical manufacturing (e.g., 10g/20g per HDPE bottle or drum) |
| Testing Indicators | Appearance — Visual inspection; Identification — LC-MS/MS, ESI-MS, or MALDI-TOF; Purity — HPLC (RP-HPLC, area percentage); Peptide content — Amino acid analysis (AAA) or UV absorbance (A280); Water content — Karl Fischer titration; Acetate/TFA content — Ion chromatography; Mass confirmation — Mass spectrometry; Bioactivity — Cell-based cAMP accumulation assay (using cells expressing GHRH receptor); Endotoxins — LAL test (for injectable grade); Residual solvents — GC; Sterility — Membrane filtration or direct inoculation (for sterile grade); Aggregation — SEC-HPLC or Dynamic Light Scattering (DLS). |
| Storage Notes | Stored as a lyophilized powder at 2–8°C (refrigerated) for short-term, or -20°C for long-term (up to 24 months). After reconstitution, store at 2–8°C and use within 24–48 hours. Protect from light, moisture, and repeated freeze-thaw cycles. |
| Lead Time | days |
Used as a growth hormone-releasing hormone (GHRH) analog for the treatment of HIV-associated lipodystrophy (excess abdominal fat). It stimulates endogenous growth hormone (GH) secretion from the pituitary gland. Research applications include metabolic disorders, growth hormone deficiency, anti-aging, and cognitive function studies.