1-Bromo-4-ethoxy-2,3-difluorobenzene
CAS: 156573-09-0
Category: Organic Intermediates
| Purity | Research Grade ≥97%; Pharmaceutical Intermediate Grade ≥98%; High Purity Grade ≥99% |
| Molecular Formula | C8H7BrF2O |
| Molecular Weight | 237.04 |
| Appearance | Colorless to pale yellow transparent liquid or low-melting solid with a characteristic aromatic odor |
| Packaging | 100 g, 500 g, 1 kg glass bottles; 5 kg, 25 kg fluorinated HDPE drums or metal containers with nitrogen protection for industrial supply |
| Testing Indicators | Appearance — Visual inspection; Purity — GC-FID or GC-MS analysis; Identification — FTIR spectroscopy and 1H/19F NMR spectroscopy; Molecular structure confirmation — LC-MS or HRMS; Water content — Karl Fischer titration (ASTM E203); Residual solvents — GC analysis according to ICH Q3C guidelines; Bromine content — ICP-OES or elemental analysis; Density — ASTM D4052 (liquid samples). |
| Storage Notes | Store in a cool, dry, well-ventilated area away from direct sunlight and heat sources. Keep container tightly sealed under inert atmosphere when possible. Avoid contact with strong oxidizing agents, strong acids, and strong bases. Protect from moisture and excessive temperature fluctuations. |
| Lead Time | 10 days |
1-Bromo-4-ethoxy-2,3-difluorobenzene is an aromatic halogenated intermediate mainly used in pharmaceutical and agrochemical synthesis. It serves as a building block for the preparation of fluorinated aromatic compounds, active pharmaceutical ingredients (APIs), specialty chemicals, and advanced materials. The bromine substituent enables further cross-coupling reactions such as Suzuki, Heck, and Buchwald-Hartwig reactions.