(R)-1-((3aR,5R,6S,6aR)-5-(((tert-Butyldiphenylsilyl)oxy)methyl)-2,2-dimethyl-6-(naphthalen-2-ylmethoxy)tetrahydrofuro[2,3-d][1,3]dioxol-5-yl)ethyl methanesulfonate
CAS: 1174917-65-7
Category: Pharmaceutical Intermediates
| Purity | Research Grade ≥98%; Chiral Grade ≥99% (HPLC); Pharmaceutical Intermediate Grade ≥99% |
| Molecular Formula | C37H44O8SSi |
| Molecular Weight | 676.90 |
| Appearance | White to off-white crystalline powder |
| Packaging | 100 mg, 500 mg, 1 g, 5 g, 10 g amber glass bottles; aluminum foil bags with moisture-proof secondary packaging for larger quantities |
| Testing Indicators | Appearance — Visual inspection; Identification — FTIR, 1H NMR, 13C NMR and 29Si NMR; Molecular mass — HRMS/LC-MS; Purity — HPLC (UV); Chiral purity — Chiral HPLC; Water content — Karl Fischer titration; Residual solvents — GC (USP <467>); Optical rotation — Polarimetry; Mesylate identity — 1H NMR and FTIR; Elemental analysis — CHNS; Related substances — HPLC impurity profiling. |
| Storage Notes | Store tightly sealed in a cool, dry place at 2–8°C. Protect from moisture, heat and direct light. Store under nitrogen or argon for long-term storage. Avoid repeated freeze-thaw cycles and prolonged exposure to humid air. |
| Lead Time | 10 days |
A highly stereochemically defined protected carbohydrate derivative used as an advanced pharmaceutical intermediate in the synthesis of antiviral nucleoside analogs and other chiral drug candidates. The tert-butyldiphenylsilyl (TBDPS) and naphthylmethyl (NAP) protecting groups provide orthogonal protection during multistep carbohydrate synthesis, while the methanesulfonate (mesylate) serves as an excellent leaving group for stereoselective nucleophilic substitution.